Lupron (leuprolide) overstimulates the body’s own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone in men or estrogen in women. Lupron is used in men to treat the symptoms of prostate cancer. Leuprolide only treats the symptoms of prostate cancer and does not treat the cancer itself. Lupron Depot is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids. Lupron Depot-Ped is used to treat precocious (early-onset) puberty in both male and female children.